Radiation hormesis: its expression in the immune system.

Radiation hormesis: its expression in the immune system.

Altruistic cell suicide in relation to radiation hormesis

Altruistic cell suicide in relation to radiation hormesis.


"The hypothesis that in animals, radiation hormesis results from altruistic cell suicide is proposed. This hypothesis can explain the hormetic effect of low doses of radiation on the immune system in mice. In contrast, in plants, radiation hormesis seems to be mainly due to non-altruistic cell death."

Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response

Excerpt from Google Book on Hormesis

Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response
Edward J. Calabrese

• In order to deny support to homeopathy, the biphasic dose response was removed from medical textbooks
• An incorrect understanding of the dose-response curve leads to worse health for populations and "extremely wasteful spending" 
• "Historical Antipathies, Rather than Science, Dominated Which Dose-Response Model Would Dominate Biology"
• Hormesis is named after the Greek word for "to excite"
• A wide assortment of terms are used to describe a hormetic or biphasic dose response curve, making it harder to study the phenomenon (since no single word has been used throughout history)

Re: TGF-beta1 in CFS impairs NRF2-ARE Phase II detox - supressing glutathione

Nrf2 protecting against glutamate toxicity, neuroprotective

"The Nrf2-ARE pathway appears to contribute to neuroprotection. First, activation of the Nrf2-ARE pathway by tert-butylhydroquinone (tBHQ) protected neuroblastoma cells from oxidative glutamate toxicity (27)"

"Overexpression of Nrf2 and small molecule-mediated activation of the Nrf2-ARE pathway in astrocytes increased resistance of neurons to non-excitotoxic glutamate toxicity (31)"

NRf2 - A multi-organ protector?

List of Nrf2-ARE inducers

Nrf2-ARE Inducers

Some of the most potent ones:

purpurogallin methyl carboxylate black tea

carnosic acid diterpene rosemary, sage

3H-1,2-dithiole-3-thione (D3T) dithiolethione Brussels sprouts, cabbage

quercetin flavonol capers, lovage, radishes, dill, cilantro, fennel leaves, red onion

curcumin polyphenol turmeric

sulforaphane isothiocyanate broccoli sprouts, broccoli, cabbage, brussels sprouts

fisetin flavonol strawberries, apples, Japanese wax tree

kahweol diterpene coffee

cafestol diterpene coffee

Could Nrf2 inhibition explain heart rate variability issues in CFS?

The influence of nrf2 on cardiac responses to environmental stressors.

Hypoxia and particulate matter caused more heart rate variability in Nrf2 knockout mice.

Could this help to explain the chronic heart rate variability issues in CFS, if CFS patients have Nrf2 inhibited for some reason (HSP, genetics, mold toxins, etc.)?

"Results demonstrate that Nrf2 deletion increases susceptibility to change in HR and HRV responses to environmental stressors and suggest potential therapeutic strategies to prevent cardiovascular alterations."