An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
HDACs need to be inhibited in order for Nrf2 to be recruited.
HDACs can also promote pro-inflammatory gene expression. This could account for more expression of IL-8, which then suppresses cortisol production.
Jason, Sorenson et al. (2011) found that elderly people with CFS/ME had elevated HDAC activity.
HDAC activity could lead to a chronic pro-inflammatory state that leads to fatigue.
